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- Bookedited by Mingjie Li and B. Joy Snider.Summary: Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system.Digital Access ScienceDirect 2018
- ArticleDupuy C, Dupuy JM.Pathol Biol (Paris). 1977 Oct;25(8):553-8.Complement (C) and C components were studied in 18 children with severe viral hepatitis. Results were compared to similar determinations performed in 8 patients with toxic hepatitis related to the ingestion of Amanita Phalloïdes. Hemolytic activities and serum concentrations of C and C components were markedly decreased (less than 2 SD) in both groups of patients. Sequential determinations of C components showed different patterns according to the outcome: either a rapid return to normal in patients who healed or persistence of low levels in patients who died. Such a pattern was similar to that of the prothrombin time. In patients with viral hepatitis a rapid disappearance of C4 and C3 was observed following fresh plasma or fresh blood transfusion. In addition, C4 cleavage was shown in plasma of 8/8 patients. These data suggest that the complement depression observed in fulminant viral hepatitis is related to both consumption and deficient synthesis.