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- Bookedited by Stephen Higgs, Dana L. Vanlandingham, Ann Powers.Summary: Chikungunya and Zika viruses provides the primary "go-to" source for both historical and current information on these increasingly important human pathogens. Both viruses are newly emerged pathogens that have recently become established in greatly expanded global ranges, to threaten hitherto unexposed populations. Epidemics since 2004 have spread from Africa and Asia to Europe and have caused millions of cases in the Americas. The viruses have probably established themselves in South and Central America permanently leaving millions at risk for future infection. Chikungunya virus (CHIKV) causes severe crippling arthritis and symptoms that can last for months or years. Infections with Zika virus (ZIKV) have been associated with potentially fatal neurological symptoms notably to children of women infected during pregnancy. There are no approved vaccines or specific treatments available. Chikungunya and Zika viruses contributes significantly to our understanding of these pathogens. This dedicated monograph brings this combined knowledge together to provide a single up-to-date source of information.
Contents:
The origins of Chikungunya and Zika viruses - History of the discoveries
Chikungunya virus and Zika virus transmission cycles
Chikungunya and Zika disease
Emergences of Chikungunya and Zika in Africa
Chikungunya and Zika virus in Asia
Chikungunya virus and Zika virus in Europe
The emergence of Chikungunya and Zika viruses in the Americas
Viral genetics of Chikungunya virus and Zika virus and its influence in their emergence and application for public health control strategies
Diagnostics and laboratory techniques
Animal models for Chikungunya virus and Zika virus
Chikungunya and Zika virus vaccines
Chikungunya and Zika: the future.Digital Access ScienceDirect 2018 - ArticleAllain P, Premel-Cabic A.Pathol Biol (Paris). 1977 Oct;25(8):535-40.The effect of metals and drugs on the activity of human erythrocyte ALA dehydratase has been studied in vitro. The most inhibitory metals are with decreasing effect silver, copper, gold and selenium. Zinc, cadmium, mercury are inhibitory at high concentrations and activator at low concentrations. Arsenic, calcium, magnesium, manganese, potassium, cobalt have no effect. Within the drugs studied the non steroidal anti-inflammatory drugs (aspirin, keptoprofen, indometacin, phenylbutazone, sodium salicylate and niflumic acid) are the only group which inhibits the enzyme ALA dehydratase. This inhibition is suppressed by zinc. The non steroidal anti-inflammatory drugs can inhibit the activity of enzymes which need zinc for optimal activity.