BookYu Zhang, editor.
Contents:
1. Historical and clinical perspectives on chromosomal translocations
2. Induction of chromosomal translocations with CRISPR-Cas9 and other nucleases: understanding the repair mechanisms that give rise to translocations
3. Dynamics of double-strand breaks: implications for the formation of chromosome translocations
4. The CRISPR/Cas9 system as a tool to engineer chromosomal translocation in vivo
5. Generation of genomic alteration from cytidine deamination
6. The role for the DSB response pathway in regulating chromosome translocations
7. Telomeres and chromosomal translocations
8. 3D genomie organization influences the chromosome translocation pattern
9. The role of chromosome deletions in human cancers
10. Processing-challenges generated by clusters of DNA double-strand breaks underpin increased effectiveness of high-LET radiation and chromothripsis.