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  • Book
    Jun Yu, editor.
    Contents:
    1. Introduction
    2. Epidemiology and etiologic associations of non-alcoholic fatty liver disease and associated HCC
    3. Pathogenesis of NASH: how metabolic complications of overnutrition favour lipotoxicity and pro-inflammatory fatty liver disease
    4. Chemokines and chemokine receptors in the development of NAFLD
    5. NAFLD related-HCC: the relationship with metabolic disorders
    6. Hepatocellular carcinoma in obesity: finding a needle in the haystack?
    7. Dysregulated epigenetic modifications in the pathogenesis of NAFLD-HCC
    8. The influence of gut microbial metabolism on the development and progression of non-alcoholic fatty liver disease
    9. Microbiota, obesity and NAFLD
    10. Autophagy, NAFLD and NAFLD-related HCC
    11. Animal models of non-alcoholic fatty liver diseases and its associated liver cancer
    12. Current prevention and treatment options for NAFLD.
    Digital Access Springer 2018
  • Book
    edited by P.L. Dubin.
    Summary: The rapid development of new packings for aqueous size-exclusion chromatography has revolutionized this field. High resolution non-adsorptive columns now make possible the efficient separation of proteins and the rapid and precise determination of the molecular weight distribution of synthetic polymers. This technology is also being applied to the separation of small ions, the characterization of associating systems, and the measurement of branching. At the same time, fundamental studies are elucidating the mechanisms of the various chromatographicprocesses. These developments in principles and applications are assembled for the first time in this book. Fundamental issues are dealt with: the roles of pore structure and macromolecular dimensions, hydrophobic and electrostatic effects, and the determination and control of column efficiency. High-performance packings based on derivatized silica are reviewed in detail. Special techniques are thoroughly described, including SEC/LALLS, inverse exclusion chromatography, and frontal zone chromatography. Nielsen 9780444429575 20160528

    Contents:
    Part I. Separation Mechanisms. Size exclusion parameters (M.E. Himmel, P.G. Squire). Partitioning: Hydrophobic interactions (M. Janado). Electrostatic effects (P.L. Dubin). Exclusion chromatography of inorganic compounds (M. Shibukawa, N. Ohta). II. Characterization of Stationary Phases. Pore size distributions (L. Hagel). Structural analysis of porous materials by measurement of size exclusion (S. Kuga). Column efficiency (S. Mori). III. New Packings. Native and bonded silicas in aqueous SEC (K.K. Unger, J.N. Kinkel). Rigid polymer gels for SEC and their application to biopolymers (K. Makino, H. Hatano). IV. Biopolymers. Biopolymers. I. Protein chromatography in denaturing and non-denaturing solvents (R.C. Montelaro). Biopolymers. II. Serum lipoproteins (M. Okazaki, I. Hara). Application of SEC/LALLS to biopolymer assemblies (K. Konishi). V. Associating Systems. Measurement of equilibrium constants by exclusion methods (T.K. Korpela, J.-P. Himanen).
    14. Frontal boundary analysis in size exclusion chromatography of self-associating proteins (G.W. Becker).
    15. Exclusion chromatography of micelles (K.S. Birdi). Subject Index. Nielsen 9780444429575 20160528
    Digital Access ScienceDirect, 1988
  • Article
    Nishikawa T, Kurihara S, Harada T, Sugawara M, Hatano H.
    Arch Dermatol Res (1975). 1977 Oct 27;260(1):1-6.
    The capability of complement fixation of pemphigus antibodies was tested using combined in vitro complement immunofluorescent (IF) staining methods. Three sera out of 25 serum samples from 22 pemphigus patients revealed positive reactions, while all other sera gave negative results. Specificity control tests confirmed the positive reactions to be specific for complement staining. Complement fixing pemphigus antibodies were titrated lower than corresponding IgG antibodies and were demonstrable only in the extensive stage of the disease. Thus, the present work supplied evidence that pemphigus antibodies fix complement in vitro. However, the discrepancy still remains between the in vivo deposition of complement in most cases of pemphigus and in vitro capability of complement fixation in only few cases. More investigations should be needed to explain the exact role of complement in pemphigus acantholysis.
    Digital Access Access Options