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  • Book
    edited by Prashant Kesharwani and Umesh Gupta.
    Summary: Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies.

    Contents:
    1. Tumors of the central nervous system: anatomy and interventional considerations
    2. Angiogenesis in brain tumors
    3. Physiology of the blood-brain barrier and mechanisms of transport across the BBB
    4. Active trageted nanoscale delivery systems for brain tumor therapeutics
    5. Nanotechnology in brain tumor targeting: efficacy and safety of nanoenabled carriers undergoing clinical testing
    6. Targeting of lipid/polymeric (hybrid) nanoparticles to the brain for the treatment of degernative diseases
    7. Biopolymeric nanoparticles for targeted drug delivery to brain tumors
    8. Solid lipid nanoparticles for targeted drug delivery
    9. Liposome-based drug delivery for brain tumor theranostics
    10. Dendrimers as effective carriers for the treatment of brain tumor - 11. Micelle-based drug delivery for brain tumors
    12. Nanemulsions-based drug delivery for brain tumors
    13. Immune infiltration in malignant gliomas
    14. Carbon nanotubes (CNTs): a novel drug delivery tool in brain tumor treatment
    15. Beyond the blood-brain barrier: facing new challenges and prospects of nanotechnology-mediated targeted delivery to the brain
    Index.
    Digital Access ScienceDirect 2018
  • Article
    Anderson JC, Burrows MR, Bramley AJ.
    Vet Pathol. 1977 Nov;14(6):618-28.
    The possible role of bacterial adherence in the pathogenesis of experimental mastitis in the mouse was examined with four strains of Escherichia coli. Two of these strains had a known adhesion antigen (K88) and two did not. The K88 antigen did not play a significant role in the virulence or infectivity of E. coli either in the murine or bovine mammary gland. Two E. coli strains, W1 (K88+) and J2 (K88-) were virulent in the mouse but did not adhere to epithelial cells. Both these strains produced clinical mastitis in the cow. A third strain, D282 (K88-), produced mild disease in the mouse but was avirulent in the cow. The fourth strain, 233/ID (K88+), was avirulent in both the mouse and the cow. Strains D282 and 233/1D were killed rapidly by bovine serum whilst J2 and W1 were more resistant. All strains were more sensitive than the control resistant strain E. coli P4, which is known to be highly virulent for the lactating udder.
    Digital Access Access Options