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  • Book
    edited by Paula B. Andrade, Patrícia Valentão, David M. Pereira.
    Summary: The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

    Contents:
    Natural products as enzyme inhibitors
    Molecular targets of clinically relevant natural products from filamentous marine cyanobacteria
    Natural angiotensin converting enzyme (ACE) inhibitors with antihypertensive properties
    Phospholipase A2 inhibitors of marine origin
    Beta-secretase (BACE1) inhibitors from natural products
    Hypoglycaemic effects of plants food constituents via inhibition of carbohydrate-hydrolysing enzymes: from chemistry to future applications
    Natural products targeting clinically relevant enzymes of eicosanoid biosynthesis implicated in inflammation and cancer
    Anti-HIV natural products
    Natural inhibitors of mitochondrial respiratory chain: therapeutic and toxicological implications
    Targeting enzymatic pathways with marine-derived clinical agents
    Anti-malarial drug discovery: new enzyme inhibitors
    Natural plant-derived acetylcholinesterase inhibitors: relevance for Alzheimer's disease.
    Digital Access Wiley 2017
  • Article
    Bradley R.
    Res Vet Sci. 1977 Sep;23(2):250-2.
    A technique employing silver impregnation can be used on frozen formalin-fixed material for demonstrating ovine motor end-plates. The morphology of ovine motor end-plates is variable but broadly similar to that described in other species. The end-plates are oval with approximate dimensions of 33 X 17 micrometer. The distal ramifications of the nerve fibre show terminal and sub-terminal vesicles. The endings are flimsy or robust and the latter have single, dual or multiple terminations.
    Digital Access Access Options