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  • Book
    edited by Alexandru Mihai Grumezescu.
    Contents:
    1. Cell and organ drug targeting: types of drug delivery systems and advanced targeting strategies
    2. Cell-penetrating peptides in nanodelivery of nucleic acids and drugs
    3. The current perspectives of nanoparticles in clellular and organ-specific drug targeting in biological system
    4. Precision medicine and drug targeting: the promise versus reality of target-specific drug delivery
    5. Brain targeting of payload using mild magnetic field: site specific delivery
    6. Nanoparticles influence in skin penetration of drugs: in vitro and in vivo characterization
    7. DNA aptamer-based molecular nanoconstructions and nanodevices for diagnostics and therapy
    8. Nanobiodevices for electrochemical biosensing of pharmaceuticals
    9. Imprinted polymeric nanoparticles as nanodevices, biosnesors and biolabels
    10. Poly(lactic-co-glycolic acid) (PLGA) matrix implants
    11. Hydrogels for biomedical applications
    12. Silk-based matrices for bone tissue engineering applications
    13. Implantable drug delivery systems: an overview
    14. Nanobionics and nanoengineered prosthetics
    Index.
    Digital Access ScienceDirect 2018
  • Article
    Young BS, Wright A.
    Mol Gen Genet. 1977 Oct 20;155(2):191-6.
    S. tyrphimurium strain BY324 is temperature sensitive due to a mutation (rpo C32) in the gene for the RNA polymerase beta' subunit. Transcription of T7 DNA by RNA polymerase purified from this strain is temperature sensitive in vitro. The enzyme is slightly defective in template binding and RNA chain initiation, but the major defect is in RNA chain elongation. The rate of RNA chain elongation is reduced 4-5 fold relative to wild-type. RNA chain termination does not appear to be affected by the beta' mutation. While the elongation defect is suppressed by glycerol or dimethylsulfoxide, the initiation defect is not. Possible roles for the beta' subunit in enzyme function are discussed in light of these results.
    Digital Access Access Options