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  • Book
    Philip C. Cory.
    Summary: Finding the Nerve: The Story of Impedance Neurography discusses research that elucidates the nature of nerve simulation via externally applied electrical fields, and how it has led to an entirely new understanding of neuronal cell membrane biophysics and defined a novel nerve imaging technology. It details how these discoveries came about and the nature of research that derives from unexplained clinical observations. The primary technology, impedance neurography, is a wholly new way of nerve-specific visualization in 2-D or 3-D, with the ability to define both normal and abnormal functioning of nerves, heretofore unavailable from techniques such as MRI neurography. This is of particular importance with respect to the obesity epidemic where physicians performing nerve-related procedures cannot use ultrasound visualization due to the depth limitations of that technology.

    Contents:
    Initial impedance neurography findings
    Skin surface impedance
    The varieties of neuronal cell membrane reactance
    Anisotropicity
    Depth determination of peripheral nerves using impedance neurography.
    Digital Access ScienceDirect 2018
  • Article
    Picken RN, Beacham IR.
    J Gen Microbiol. 1977 Oct;102(2):305-18.
    A series of mutants of Escherichia coli K12 resistant to lipopolysaccharide (LPS)-specific bacteriophages were isolated, and examined with regard to their general properties, phage typing, chemical analysis of their LPS, and genetic analysis. Fourteen classes of mutants were distinguished on the basis of phage typing and sensitivity to bile salts. Three of the mutant classes are sensitive to phages to which the parent is resistant. Mutants which are sensitive to bile salts generally lack heptose in their LPS, but two mutant classes are exceptions to this rule. Analyses of the sugars in the purified LPS of all mutant classes indicated that mutants were obtained which are blocked at most stages in core polysaccharide synthesis. On the basis of the chemical analysis, in conjunction with phage typing data and other known properties of the mutants, it is deduced which residue(s) is involved as a receptor for each of the phages used and which residues hinder these receptors. Some of the mutant classes do not seem to be changed in their LPS structure. Many of the mutations map in or near the rfa locus, but some are far removed from this region.
    Digital Access Access Options