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- ArticleRamsden RT, Moffat DA, Gibson WP, Jay MM.J Laryngol Otol. 1977 Oct;91(10):847-51.A double blind trial was carried out comparing S-carboxymethylcysteine (S-CMC; Mucodyne, Berk Pharmaceuticals) with inert placebo in the treatment of glue ear in fifty-two children who had not previously undergone surgery for the condition. The results, analysed after three months of treatment failed to demonstrate a significant reduction in the number of children receiving S-CMC who eventually required surgery for the condition.