Bookedited by Eric Marsault, University of Sherbrooke, Quebec, Canada, Mark L. Peterson, Quebec, Canada.
Contents:
1. Contemporary macrocyclization technologies
2. A practical guide to structural aspects of macrocyles (NMR, X-Ray and Modeling)
3. Designing orally bioavailable peptide and peptoid macrocycles
4. Natural and nature-inspired macrocycles: a chemoinformatic overview and relevant examples
5. Bioactive and membrane-permeable cyclic peptide natural products
6. Chemical approaches to macrocycle libraries
7. Biological and hybrid biological/chemical strategies in diversity generation of peptidic macrocycles
8. Macrocycles for protein-protein interactions
9. Synthetic strategies for macrocyclic peptides
10. Ring-closing metathesis-based methods in chemical biology: building a natural product-inspired macrocyclic toolbox to tackle protein-protein interactions
11. the synthesis of peptide-based macrocycles by Huisgen Cycloaddition
12. Palladium-catalyzed synthesis of macrocycles
13. Alternative strategies for the construction of macrocycles
14. Macrocycles from multicomponent reactions
15.Synthetic approaches used in the scale-up of macrocyclic clinical candidates
16. Overview of macrocycles in cllinical development and clinically used
17. The discovery of macrocyclic IAP inhibitors for the treatment of cancer
18. Discovery and pharmacokietic-pharmacodynamic evaluation of an orally available novel macrocyclic inhibitor of anaplastic lymphoma kinase and c-Ros oncogene 1
19. Optimization of macrocyclic ghrelin receptor agonist (Part II): development of TZP-102
20. Solithromycin: fourth generation macrolide antibiotic
Index.