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  • Book
    Barnali Chaudhuri, Inés G. Muñoz, Shuo Qian, Volker S. Urban, editors.
    Contents:
    Sample and Buffer preparation for SAXS
    Considerations for sample preparation using size-exclusion chromatography
    How to analyze and present SAS data for publication
    Designing and Performing Biological Solution Small-Angle Neutron Scattering Contrast Variation Experiments on Multi-component Assemblies
    SAS-based structural modeling and model validation
    Structural Characterization of Highly Flexible Proteins by Small-Angle Scattering
    What can we learn from wide-angle solution scattering?
    SAS-based studies of protein fibrillation
    High Resolution Distance Distributions Determined by X-ray and Neutron Scattering
    A successful combination: coupling SE-HPLC with SAXS
    Applications of SANS to study membrane protein systems
    Hybrid applications of solution scattering to aid structural biology
    A practical guide to iSPOT modeling: An integrative structural biology platform
    Small angle scattering for pharmaceutical applications: From drugs to drug delivery system.
    Digital Access Springer 2017
  • Article
    Ring J, Hedin H, Richter W, Jesch F, Messmer K.
    Eur Surg Res. 1977;9(5):338-46.
    A high molecular weight component (HMC) of autolysate from Saccharomyces cerevisiae yeast cells was prepared. HMC was found to be immunogenic in dogs, inducing hemagglutinating antibody formation. Upon HMC challenge of immunized dogs, systemic anaphylactoid reactions were observed in 4/5 animals. The most prominent symptom was decreased cardiac output. Decrease in mean arterial pressure and increase in pulmonary arterial pressure were also observed. Consumption of total serum complement activity amounted to 22% of initial values. HMC also exhibited mitogenic activity in lymphocyte cultures from nonimmunized and immunized dogs. Since yeast autolysate is used as nitrogen source for Leuconostoc mesenteroides in the production of clinical B 512 dextran it is a theoretically possible trace contaminant of such solutions. Therefore, dogs hyperimmunized with HMC were also challenged with clinical dextran. No anaphylactoid signs were observed. These data suggest a negligible causal role of macromolecular contaminants derived from yeast cell autolysate in rare human anaphylactoid reactions following infusion of clinical dextran.
    Digital Access Access Options