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  • Book
    Franck Mauvais-Jarvis, editor.
    Contents:
    Part I. Sex differences in diabetes and obesity
    Part II. Role of estrogens in metabolic homeostasis
    Part III. Impact of androgens in metabolic homeostasis and disease
    Part IV. Transgender biology and metabolism.
    Digital Access Springer 2017
  • Book
    Maria Niewiadomska.
    Print 1989
  • Article
    Sandermann H.
    Eur J Biochem. 1977 Nov 01;80(2):507-15.
    1. A number of galactosides and other sugar compounds were examined as inhibitors of facilitated or active transport by the lactose permease system of Escherichia coli. Efficient inhibition required an alpha- or beta-anomeric galactopyranosyl ring of D-configuration, a free 6-hydroxyl group, and a certain aglycone size which was reached, for example, by monosaccharide or nitrophenyl substituents. 2. Aromatic alpha-D-galactopyranosides acted as high-affinity inhibitors (Ki, below 50 micrometer). At least two of them were not transported, in contrast to alpha-galactoside disaccharides and to aromatic beta-D-galactopyranosides. 3. beta-D-Galactoside transport was not significantly inhibited by specific inhibitors and transitionstate analogues of beta-galactosidase (D-galactal, D-galactonolascone). 4. The beta-D-galactopyranoside, lactitol, and alpha-D-galactopyranoside, galactinol, were not efficiently bound by the lactose permease system, although the maximal rate of uptake of lacitol was similar to that of lactose. By comparison with several structurally related D-galactopyranosides, the decreased affinity was attributed to an effect of the membrane/water interface. A model for substrate recognition by the lactose permease system is presented.
    Digital Access Access Options