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- BookR. Douglas Collins.Contents:
Taking a history of the patient with neck pain
Examination of the patient with neck pain
Diagnosis of the patient with neck pain
Conservative management with the patient with neck pain
Illustrated cases of neck pain
Taking a history of the patient with thoracic pain
Examination of the patient with thoracic pain
Diagnosis of the patient with thoracic pain
Conservative management of the patient with thoracic pain
Illustrated cases of thoracic pain
Taking a history of the patient with low back pain
Examination of the patient with low back pain
Diagnosis of the patient with low back pain
Conservative management of the patient with low back pain
Illustrated cases of low back pain.Digital Access Ovid 2018 - ArticleKonturek SJ, Swierczek J, Kwiecień N, Mikoś E, Oleksy J, Wierzbicki Z.Am J Dig Dis. 1977 Nov;22(11):981-8.The effect of somatostatin, a growth hormone releasing-inhibiting hormone (GH-RIH) on basal and meal-, pentagastrin-, or histamine-stimulated gastric acid and pepsin secretion was studied in six duodenal ulcer patients. Intravenous GH-RIH infused in graded doses ranging from 0.62 to 5.0 microgram/kg/hr produced a dose-related inhibition of pentagastrin-induced acid secretion reaching about 15% of control level at the dose of 5.0 microgram/kg/hr. Acid inhibition was paralleled by a decrease in the pepsin output and accompanied by a dose-dependent reduction in serum growth hormone and insulin levels measured by radioimmunoassay. GH-RIH used in a single dose of 2.5 microgram/kg/hr produced about 85% inhibition of acid secretion induced by a meal (measured by intragastric titration) accompanied by a significant decrease in serum gastrin and insulin levels. The effect of GH-RIH on histamine-stimulated secretion was very modest and observed only after stopping the GH-RIH infusion. Thus GH-RIH suppressed acid and pepsin secretion induced by pentagastrin and a meal, and this effect was accompanied by a suppression of serum growth hormone and gastrin levels which may contribute to the inhibition of gastric secretion observed.