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  • Book
    Lewis Landsberg, MD, Irving S. Cutter Professor of Medicine, dean emeritus, director, Northwestern Comprehensive Center on Obesity (NCCO), Northwestern University Feinberg School of Medicine, Chicago, IL.
    Contents:
    Machine generated contents note: pt. I Fundamental Aspects of Catecholamine Biology
    Introduction: Overview of the Sympathoadrenal System
    Biosynthesis of Catecholamines
    Catecholamine Storage and Release from Sympathetic Nerve Endings and Adrenal Medullary Chromaffin Cells
    Regulation of Central Sympathoadrenal Outflow
    The Peripheral Dopaminergic System
    Metabolism and Termination of Action of Catecholamines
    Adrenergic Receptors
    Assessment of Sympathoadrenal Activity
    pt. II Physiology of the Sympathoadrenal System
    General and Unique Features of Regulation by the Sympathoadrenal System: Central Neural Control
    Cardiovascular Effects of the Sympathoadrenal System
    Metabolic Effects of the Sympathoadrenal System
    Sympathetic Nervous System Effects on Heat Conservation and Heat Generation
    Sympathoadrenal Effects on Visceral Smooth Muscle and Exocrine Glands
    Sympathoadrenal Effects on Renal Function, Electrolytes, and Hormone Secretion
    pt. III The Role of the Sympathoadrenal System in Physiologic Adaptation and the Pathophysiology of Disease States
    Cold Exposure
    Exercise and Physical Training
    Dietary Intake: Fasting and Overfeeding
    Hypoglycemia
    Ketosis, Ketogenesis, and Ketoacidosis
    Hypertension
    Obesity
    Hypoxia and Hypercarbia (Hypercapnia)
    Congestive Heart Failure
    Thyroid and Adrenal Hormones
    Hypotension and Shock
    pt. IV Pharmacology
    Adrenergic Agonists
    Adrenergic Antagonists
    Drugs Affecting the Metabolism and the Inactivation of Catecholamines
    pt. V Tumors of the Sympathoadrenal System
    Pheochromocytoma
    Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma.
    Digital Access Ovid 2017
  • Article
    Barnett EV.
    Am J Clin Pathol. 1977 Nov;68(5 Suppl):662-3.
    The value of clinical laboratory tests as aids in diagnosis and prognosis depends on their sensitivity, specificity, and accuracy. Few tests fulfill the desirable criteria for use as screening tests in the asymptomatic, normal population. In the symptomatic patient a test of high sensitivity for detecting disease has great clinical value since a negative result tends to exclude the index diagnosis for consideration at that point in time. A test of high specificity for a single disease invariably has decreased sensitivity but has diagnostic value when positive. Data on the indirect immunofluorescent antinuclear antibody test (FANA) provide criteria to justify its wide application as a clinical laboratory test. A negative FANA result essentially excludes active systemic lupus erythematosus (SLE). Quantitation by serum titration of the positive FANA and attention to the nuclear fluorescence patterns provide indices of specificity for diagnosis of the various FANA-positive autoimmune diseases. Similarly, negative results of indirect fluorescent antibody tests for antithyroid antibodies essentially exclude Hashimoto's thyroiditis, and a negative test for antimitochondrial antibodies in biliary cirrhosis tends to exclude the surgically amenable form due to biliary stones.
    Digital Access Access Options