Bookedited by Donald Huddler, Edward R. Zartler.
Summary: "This book is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns"--Provided by publisher.
Contents:
Introduction
Thermodynamics in drug discovery
Tailoring hit identification and qualification methods for targeting protein-protein interactions
Hydrogen-deuterium exchange mass spectrometry in drug discovery - theory, practice and future
Microscale thermophoresis in drug discovery
SPR screening: applying the new generation of SPR hardware
Weak affinity chromatography (WAC)
1D NMR methods for hit identification
Protein-based NMR methods applied to drug discovery
Applications of ligand and protein-observed NMR in ligand discovery
Using biophysical methods to optimize compound residence time
Applying biophysical and biochemical methods to the discovery of allosteric modulators of the AAA ATPase p97
Driving drug discovery with biophysical information: application to Staphylococcus aureus Dihydrofolate reductase (DHFR)
Assembly of fragment screening libraries: property and diversity analysis.