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  • Book
    edited by Bert M?uller and Marcel Van de Voorde.
    Summary: Unique in combining the expertise of practitioners from university hospitals and that of academic researchers, this timely monograph presents selected topics catering specifically to the needs and interests of natural scientists and engineers as well as physicians who are concerned with developing nanotechnology-based treatments to improve human health. To this end, the book cover the materials aspects of nanomedicine, such as the hierarchical structure of biological materials, the imaging of hard and soft tissues and, in particular, concrete examples of nanotechnology-based approaches in modern medical treatments. The whole is rounded off by a discussion of the opportunities and risks of using nanotechnology and nanomaterials in medicine, backed by case studies taken from real life.

    Contents:
    Part I. Introduction to nanoscience in medicine of the twenty-first century
    Chapter 1. Challenges and opportunities of nanotechnology for human health
    Chapter 2. Nanoscience and nanotechnology and the armory for the twenty-first centrury health care
    Chapter 3. Nanomedicine activities in the United States and worldwide
    Part II. Leading cause of death: cardiovascular diseases
    Chapter 4. Challenges in cardiovascular treatments using nanotechnology-based approaches
    Chapter 5. Smart container for targeting drug delivery
    Chapter 6. Human nano-vesicles in physiology and pathology
    Chapter 7. Challenges and risks of nanotechnology in medicine: an immunologist's point of view
    Part III. Second most common cause of death: cancer
    Chapter 8.Challenges of applying targeted nanostructures with multifunctional properties in cancer treatments
    Chapter 9. Highly conformal radiotherapy using protons
    Chapter 10. Self-organization on a chip: from nanoscale actin assemblies to tumor spheroids
    Chapter 11. The nanomechnaical signature of tissues in health and disease
    Part IV. Most common diseases: caries, musculoskeletal diseases, incontinence, allergies
    Chapter 12. Revealing the nano-architecture of human hard and soft tissues by spatially resolved hard X-Ray scattering
    Chapter 13. Regenerative dentistry using stem cells and nanotechnology
    Chapter 14. Nanostructured polymers for medical applications
    Chapter 15. Nanotechnology in the treatment of incontinence
    Chapter 16. Nanomedicine in dermatiology: nanotechnology in prevention, diagnosis, and therapy
    Part V. Benefiting patients
    Chapter 17. Therapeutic development and the evolution of precision medicine
    Chapter 18. Benefit from nanoscience and nanotechnology: benefitting patients
    Index.
    Digital Access Wiley 2017
  • Article
    Mookenthottathil T.
    Oncology. 1977;34(5):201-4.
    The influence of environmental carcinogens on the developing embryo has been investigated using SWA mice as models and 1-ethyl-1-nitrosourea (ENU) as the carcinogen. The percentage of tumor development among the F1 generations of siblings delivered and nursed by mothers treated with ENU was higher than that of the F1 generations of siblings delivered of treated mothers but nursed by untreated foster mothers. The presence of multople tumors was also more frequent in this group compared to the siblings which were exposed only transplacentally to ENU. The second generations also developed malignant tumors. Two successive generations of siblings which were delivered of untreated mothers but nursed by foster mothers treated with ENU on the 12th day of pregnancy, showed a higher percentage of tumors when compared to the control group. This result is of great significance as the siblings were not exposed to the carcinogen transplacentally, and the foster mothers were treated with only a single dose of ENU long before the lactating period, namely, on the 12th day of pregnancy.
    Digital Access Access Options