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  • Book
    Sebastien Gagneux, editor.
    Contents:
    1. The nature and evolution of genomic diversity in the Mycobacterium tuberclosis complex
    2. The biology and epidemiology of Mycobacterium canettii
    3. The evoluation of strain typing in the Mycobacterium tuberculosis complex
    4. Genomic epidemiology of tuberculosis
    5. Biological and epidemiological consequences of MTBC diversity
    6. The biology and epidemiology of Mycobacterium africanum
    7. Mycobacterium tuberculosis complex members adapted to wild and domestic animals
    8. Evolution and strain variation in BCG
    9. Antigenic variation and immune escape in the MTBC
    10. PE and PPE genes: a tale of conservation and diversity
    11. Epidemiology of drug-resistant tuberculosis
    12. Evolution of phenotypic and molecular drug susceptibility testing
    13. DNA replication fidelity in the Mycobacterium tuberculosis complex
    14. Strain diversity and the evolution of antibiotic resistance
    15. Mathematical models for the epidemiology and evolution of Mycobacterium tuberculosis
    Index.
    Digital Access Springer 2017
  • Book
    Andrew Wohlgemuth.
    Print c1990
  • Article
    Snipes CE, Brillinger GU, Sellers L, Mascaro L, Floss HG.
    J Biol Chem. 1977 Nov 25;252(22):8113-7.
    The stereochemical course of the dTDP-glucose oxidoreductase (EC 4.2.1.46) reaction was studied using enzyme partially purified from Escherichia coli and dTDP-(6R)- and (6S)-[4-2H, 6-3H]glucose as substrate. The latter was prepared enzymatically by reduction of (3R)- and (3S)-3-P-[3-3H]glycerate to the 1-deuterated 3-P-glyceraldehyde with (4S)-[4-2H]NADH, followed first by conversion to glucose-1-P with the glycolytic enzymes, and then by transformation into the dTDP derivative. The stereospecifically labeled dTDP-glucose samples were mixed with nonlabeled carrier material and converted to dTDP-4-keto-6-deoxyglucose, which contained a chiral methyl group as shown by chirality analysis of the acetic acid resulting from Kuhn-Roth oxidation of the sugar nucleotide. These results confirm that the hydrogen transfer from C4 to C6 is intramolecular and show that the migrating hydrogen replaces the 6-hydroxyl group with inversion of configuration. Assuming that the hydrogen transfer, since it is intramolecular, must be suprafacial, it follows that the elimination of water from C5 and C6 is formally syn, whereas the reduction of the resulting delta5,6-double bond formally involves an anti addition of H+ and H-.
    Digital Access Access Options