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  • Book
    edited by Debra Nestel, Michelle Kelly, Brian Jolly, Marcus Watson.
    Contents:
    Section I. Introduction
    Section II. Theoretical perspectives and frameworks for healthcare simulation
    Section III. Contemporary issues in healthcare simulation
    Section IV. Elements of simulation practice
    Section V. Innovations in healthcare simulation practice
    Section VI. Conclusions and future practice.
    Digital Access Wiley 2018
  • Article
    Marsh JW, Denis J, Wriston JC.
    J Biol Chem. 1977 Nov 10;252(21):7678-84.
    Reductive coupling with sodium cyanoborhydride has been used with lactose and N-acetylneuraminyl lactose to prepare glycosylated Escherichia coli L-asparaginase. A substantial degree of modification can be achieved without significant loss of enzyme activity. The lactosylated enzyme shows increased thermal stability and resistance to proteolytic cleavage and is cleared more rapidly from the plasma of mice, compared to native asparaginase. The effect on clearance varies directly with the degree of lactosylation. Asparaginase modified with N-acetylneuraminyl lactose, in contrast, with approximately 13.6 mol of N-acetylneuraminyl lactose/mol of enzyme, is cleared more slowly, with a t 1/2 that is approximately twice that of the native enzyme.
    Digital Access Access Options