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  • Book
    Susanne Sattler, Teresa Kennedy-Lydon, editors.
    Summary: "Cardiovascular immunology is a newly emerging research area, investigating the crosstalk between the cardiovascular and the immune system. This crosstalk is evident through (1) crucial immunological capacities and functions of cardiovascular cell types, including cardiomyocytes, fibroblasts, endothelial cells, pericytes and cardiac resident macrophages, (2) the impact of aberrant immune function on the development of cardiovascular disease such as atherosclerosis, direct and indirect immune-mediated heart disease and vasculitis, and (3) the crucial role of the immune system in cardiac repair and regeneration. The Immunology of Cardiovascular Homeostasis and Pathology covers all these aspects of cardiovascular immunology, starting with homeostatic immunological functions of traditional cardiovascular cell types, and moving then to the role of the immune system in cardiovascular pathology and to recent research into targeting the immune system to boost cardiac healing and regeneration"--Publisher's description.

    Contents:
    The immune system in tissue and organ homeostasis. The role of the immune system beyond the fight against infection / Susanne Sattler
    Immune functions and properties of resident cells in the heart and cardiovascular system. Paying for the tolls: the high cost of the innate immune system for the cardiac myocyte / Anne A. Knowlton
    Properties and immune function of cardiac fibroblasts / Milena B. Furtado, Muneer Hasham
    Endothelial cells / Caterina Sturtzel
    Immune functions and properties of resident cells in the heart and cardiovascular system: pericytes / Teresa Kennedy-Lydon
    The role of cardiac tissue macrophages in homeostasis and disease / Alexei Ilinykh, Alexander R. Pinto
    The immune system in cardiovascular pathology. Atherosclerosis / Mohammed Shamim Rahman, Kevin Woollard
    Immune-mediated heart disease / Elena Generali, Marco Folci, Carlo Selmi, Piersandro Riboldi
    Vasculitis in the central nervous system / Anastasia Bougea, Nikolaos Spantideas
    Cardiac autoimmunity: myocarditis / William Bracamonte-Baran, Daniela Čiháová-- The immune system in repair and regeneration after myocardial infarct. Lymphocytes at the heart of wound healing / Vânia Nunes-Silva, Stefan Frantz, Gustavo Campos Ramos
    The innate immune response in myocardial infarction, repair, and regeneration / Rebecca Gentek, Guillaume Hoeffel.
    Digital Access Springer 2017
  • Article
    Fast R, Sköld O.
    J Biol Chem. 1977 Nov 10;252(21):7620-4.
    The regulation of uracil uptake in bacteria was studied in bacteriophage T4-infected cells, where host-specific, stable RNA synthesis is completely shut-off by phage, and where phage-specific RNA synthesis, which is not stringently regulated, could be followed by a continuous incorporation of uracil. This incorporation into phage RNA was found to be dependent on the allelic state of the rel gene and it was thus severely restricted under stringent conditions. This was not the case with adenine, which was incorported into RNA to almost the same extent under stringent and relaxed conditions, respectively. The inhibition of uracil uptake under proceeding RNA formation, which was furthermore found to be reversed by addition of chloramphenicol, indicated a specific mechanism governing the cellular entry of uracil. This is suggested to involve the allosteric regulation of uracil phosphoribosyltransferase (EC 2.4.2.9.). The enzyme was partially purified by ammonium sulfate precipitation and gel chromatography. The dependence on GDP and GTP as positive effectors was demonstrated. The stimulatory effect of GTP was abolished in vitro by the addition of guanosine 5'-diphosphate 3-diphosphate, which is known to accumulate during amino acid starvation in stringent bacteria. The reversible inactivation of the enzyme by dilution suggested a subunit structure of uracil phosphoribosyltransferase.
    Digital Access Access Options