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- ArticleSmith PH, Merchant FW, Johnson DG, Fujimoto WY, Williams RH.Am J Anat. 1977 Aug;149(4):585-90.In rat pancreatic islets, the glucagon-producing A-cells also contain a GIP-like material as revealed by the peroxidase-antiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross-reactivity of anti-GIP with glucagon. It is concluded either that the A-cells synthesize a GIP-like peptide or that it is taken up from the circulation.