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- Bookeditor, Laurence L. Brunton ; associate editors, Björn C. Knollmann, Randa Hilal-Dandan.Contents:
Section I: General principles. Drug invention and the pharmaceutical industry
Pharmacokinetics: the dynamics of drug absorption, distribution, metabolism, and elimination
Drug toxicity and poisoning
Membrane transporters and drug response
Drug metabolism
Pharmacogenetics
Section II: Neuropharmacology. Muscarinic receptor agonists and antagonists
Anticholinesterase agents
Nicotine and agents acting at the neuromuscular junction and autonomic ganglia
Adrenergic agonists and antagonists. - ArticleMikhail GR, Nims LP, Kelly AP, Ditmars DM, Eyler WR.Arch Dermatol. 1977 Sep;113(9):1261-9.In 93 reported cases of metastatic basal cell carcinoma (BCC), 76 had spread through lymphatics or blood vessels. Two more cases are presented, bringing the total to 78. Metastasis to regional lymph nodes was the most frequent, followed in frequency by lungs, bones, and other organs. The size of the primary tumor, its site, its resistance to x-ray therapy, and the effects of radiation appeared to contribute to the occurrence of metastasis. However, in an appreciable number of cases, tumor dissemination was related to incomplete excision followed by immediate wound closure, particularly by grafting. It is recommended that wound grafting be delayed for at least six months after excision or large or recurrent BCC in order to assure complete removal.