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- BookHiroshi Shibasaki, MD, PhD, Emeritus Professor, Kyoto University Graduate School of Medicine, ... Show More Kyoto, Japan, Mark Hallett, MD, Chief, Human Motor Control Section, National Institution of Neurological Disorders and Stroke, National Institute of Health, Bethesda, Maryland, President, International Federation of Clinical Neurophysiology.Digital Access Oxford 2016
- ArticleBitar KG, Firca JR, Loper JC.Biochim Biophys Acta. 1977 Aug 23;493(2):429-40.The purification and some physical properties of histidinol dehydrogenase, L-histidinol-nicotinamide adenine dinucleotide oxido-reductase (EC 1.1.1.23) from either Salmonella typhimurium or Escherichia coli are reported in this paper. Modification of histidinol dehydrogenase with one equivalent of N-(4-dimethylamino-3,5-dinitrophenyl)maleimide at pH 6.8 yields an enzyme that is inactive toward the oxidation of L-histidinol. The modified cysteine residue was located in an acid insoluble tryptic core. The amino acid sequence around the reactive thiol group in S. typhimurium is: Leu-Cys-Gly-Val-Glu-Glu-Ile-Phe, and in E. coli is: Leu-Cys-Gly-Val-Glu-Asp-Val-Phe. These unique sequences show no homology to the reactive thiol groups from some other dehydrogenases.