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  • Book
    Kim E. Barrett, Susan M. Barman, Scott Boitano, Jane F. Reckelhoff.
    Contents:
    Section I. Cellular & molecular basis for medical physiology : General principles & energy production in medical physiology ; Overview of cellular physiology in medical physiology ; Immunity, infection, & inflammation ; Excitable tissue: nerve ; Excitable tissue: muscle ; Synaptic & junctional transmission ; Neurotransmitters & neuromodulators
    Section II. Central & peripheral neurophysiology : Somatosensory neurotransmission: touch, pain, & temperature ; Vision ; Hearing & equilibrium ; Smell & taste ; Reflex & voluntary control of posture & movement ; Autonomic nervous system ; Electrical activity of the brain, sleep--wake states, & circadian rhythms ; Learning, memory, language, & speech
    Section III. Endocrine & reproductive physiology : Basic concepts of endocrine regulation ; Hypothalamic regulation of hormonal functions ; The pituitary gland ; The thyroid gland ; The adrenal medulla & adrenal cortex ; Hormonal control of calcium & phosphate metabolism & the physiology of bone ; Reproductive development & function of the female reproductive system ; Function of the male reproductive system ; Endocrine functions of the pancreas & regulation of carbohydrate metabolism
    Section IV. Gastrointestinal physiology : Overview of gastrointestinal function & regulation ; Digestion, absorption, & nutritional principles ; Gastrointestinal motility ; Transport & metabolic functions of the liver
    Section V. Cardiovascular physiology : Origin of the heartbeat & the electrical activity of the heart ; The heart as a pump ; Blood as a circulatory fluid & the dynamics of blood & lymph flow ; Cardiovascular regulatory mechanisms ; Circulation through special regions
    Section VI. Respiratory physiology : Introduction to pulmonary structure & mechanics ; Gas transport & pH ; Regulation of respiration
    Section VII. Renal physiology : Renal function & micturition ; Regulation of extracellular fluid composition & volume ; Acidification of the urine & bicarbonate excretion.
    Digital Access AccessMedicine 2018
  • Article
    Eckstein F, Sternbach H, von der Haar F.
    Biochemistry. 1977 Jul 26;16(15):3429-32.
    Isomer A of adenosine 5'-O-(1-thiotriphosphate) (ATP alpha S) is a substrate for tRNA nucleotidyltransferase from baker's yeast, whereas isomer B is a competitive inhibitor. The tRNA resulting from this reaction has a phosphorothioate instead of a phosphate diester linkage at the last internucleotidic linkage between cytidine and adenosine. On limited digestion of this tRNA with RNase A, one can isolate cytidine 2',3'-cyclic phosphorothioate which can be deaminated to uridine 2',3'-cyclic phosphorothioate. It can be shown that this compound is the endo isomer and that, therefore, the phosphorothioate diester bond in the tRNA must have had the R configuration. This result indicates that no racemization during the condensation of ATP alpha S, isomer A, onto the tRNA had occurred. Whether inversion or retention of configuration had taken place awaits elucidation of the absolute configuration of isomer A of ATP alpha S.
    Digital Access Access Options