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  • Book
    edited by Slobodan Vukicevic, Kuber T. Sampath.
    Contents:
    Historical perspective of bone morphogenetic proteins
    The systems biology of bone morphogenetic proteins
    Embryonic skeletogenesis and craniofacial development
    BMP and BMP regulation: structure and function
    Novel in vitro assay models to study osteogenesis and chondrogenesis for human skeletal disorders
    Toward advanced therapy medicinal products (ATMPs) combining bone morphogenetic proteins (BMP) and cells for bone regeneration
    BMP signaling in articular cartilage repair and regeneration: potential therapeutic opportunity for osteoarthritis
    BMPs in orthopaedic medicine: promises and challenges
    Osteogrow: a novel graft substitute for orthopedic reconstruction
    Biology of spine fusion and application of osteobiologics in spine surgery
    BMPs in dental medicine: promises and challenges
    Bone morphogenetic protein-7 and its role in acute kidney injury and chronic kidney failure
    Bone morphogenetic protein signaling in pulmonary arterial hypertension
    BMP signaling in fibrodysplasia ossificans progressiva, a rare genetic disorder of heterotopic ossification
    The central role of BMP signaling in regulating iron homeostasis
    BMPs in inflammation
    Physiological and pathological consequences of vascular BMP signaling
    Bone morphogenetic proteins in the initiation and progression of breast cancer.
    Digital Access Springer 2017
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2017
    QP552.B65 B664 2017
    1
  • Article
    Chu EH, Trosko JE, Chang CC.
    J Toxicol Environ Health. 1977 Jul;2(6):1317-34.
    A number of circumstantial lines of evidence are consistent with the somatic mutation theory of carcinogenesis, but there has been a paucity of experimental data that either support or contradict the genetic theory. In this paper, we summarize the predictions, the recent experimental approaches, and the problems involved in testing the theory. Results are presented that define the conditions and demonstrate the existence of two-stage processes of mutagenesis and carcinogenesis in vitro. We conclude that mutagenesis is responsible for the initiation of carcinogenesis and an epigenetic mechanism is responsible for its promotion. Carcinogenic agents can induce a stable transformation of a cell by either mutation or epigenetic alteration in gene expression. This conclusion has led us to propose a new integrative theory of carcinogenesis, encompassing the tenets of four main theories: (1) the mutation and epigenetic basis for carcinogenesis, (2) the two-stage theory of carcinogenesis, (3) a general theory of carcinogenesis, and (4) the somatic deletion mutation theory of carcinogenesis.
    Digital Access Access Options