Host response to implanted materials and devices, overview -- Innate and acquired immunity: umoral and cellular components (Protein adsorption, cell recruitment, tissue response) -- Acute/Chronic inflammation, foreign body reaction -- implications -- Macrophages: from immune response to tissue restoration -- Host response to cell-grafted biomaterials -- Host response to therapeutic nanoparticles -- Host response to synthetic versus natural biomaterials (The effects of the composition, structure on function, stability, and final outcome) -- Biomimicry at the cell-material interface to mitigate the immune reaction -- Bioactive materials design for immunomodulation. exploiting the patient's own body machinery to achieve functional tissue restoration -- Host response to materials for orthopaedic applications: current approaches and future perspectives -- Methods to activate cellular immunity or determine immune evasion.