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  • Book
    Katlein França, Mohammad Jafferany, editors.
    Summary: Dermatological conditions are intimately related to stress. Stress can affect, reveal or even exacerbate a number of skin disorders, including alopecia, seborrheic dermatitis, psoriasis, atopic dermatitis, pruritus, herpes, lichen planus, rosacea and urticarial. On the other hand, the skin disease itself could induce a secondary stress for the patient, influencing his or her quality of life. There is increasing evidence that stress influences disease processes and contributes to inflammation through the modulating hypothalamicpituitary- adrenal axis - releasing neuropeptides, neurotrophins, lymphokines and other chemical mediators from nerve endings to dermal cells. This is one of the first books published on this topic, focusing more on the basic science aspects of stress in dermatopathology (oxidants, antioxidants, and oxidative injury in dermatopathology, dermatopharmacology, and dermatotoxicology.) Most Psychodermatology texts adopt a practical approach to identify all types of Psychodermatology disorders, focusing on clinical treatment. This concise title offers a comprehensive and didactic approach to skin diseases caused or exacerbated by stress, as well as covers the immunology, role and effect of stress on skin disease, and quality of life in dermatology. In the current programs of medical residency in dermatology, little is taught about the relationship between stress and skin diseases and this book is an important tool for young dermatologists and psychodermatologists in training. .
    Digital Access Springer 2017
  • Article
    Burd JF, Wong RC, Feeney JE, Carrico RJ, Boguslaski RC.
    Clin Chem. 1977 Aug;23(8):1402-8.
    We applied a homogeneous reactant-labeled fluorescent immunoassay to the measurement of therapeutic drug concentrations in human serum, exemplified here by gentamicin. A derivative of umbelliferyl-beta-galactoside was coupled covalently to the drug and this conjugate was found to be nonfluorescent under assay conditions. The drug/dye conjugate was a substrate for bacterial beta-galactosidase and yielded a fluorescent product. When the drug/dye conjugate was bound to anti-gentamicin antibody it was inactive as an enzymatic substrate. This inactivation was relieved by the presence of gentamicin in competitive binding reactions. Hence, the rate of production of fluorescence was proportional to the gentamicin concentration. The fluorescent assay yielded values which compared favorably to a radioimmunoassay for gentamicin in clinical serum samples (r=0.94, standard error of estimate=0.66 mg/liter). The fluorescent assay requires only 1 microliter of serum and offers several advantages over existing techniques: sensitivity, specificity, simplicity, and the obviation of radioisotopes.
    Digital Access Access Options