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• Book

  Measurement and Analysis in Transforming Healthcare Delivery. Volume 1, Quantitative Approaches in Health Systems Engineering

  Peter J. Fabri.

  Contents:
  Introduction to Measurement and Analysis
  Data and Types of Data
  Software for Analytics
  Measurement and Uncertainty
  Mathematical and Statistical Concepts in Data Analysis
  Analysis by Modeling Data
  Principles of Supervised Learning
  Unsupervised Machine Learning
  Datasets Without Outcomes
  Survival Analysis
  Interpreting Outcomes: Cause and Effect and p-values
  Useful Tools.

  Digital Access Springer 2016
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• Article

  The pathogenesis of experimental bladder cancer.

  Bryan GT.

  Cancer Res. 1977 Aug;37(8 Pt 2):2813-6.

  The pathogenesis of signal morphological lesions of the urinary bladder induced in several species following administration of N-butyl-N-(4-hydroxybutyl)nitrosamine, bracken fern, or N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide is presented. Incidences of bladder neoplasia exceeding 80% were generated in the rat by each compound. Bladder neoplasia was induced in the following species by each substance: by N-butyl-N-(4-hydroxybutyl)nitrosamine in the mouse, hamster, guinea pig, and dog; by bracken fern in the guinea pig, mouse, and cow; and by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in mouse, hamster, and dog. The guinea pig appeared resistant to the bladder oncogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Different species displayed a gradient of bladder neoplastic responsiveness. Hyperplasia was a consistent early lesion and was usually focal. Early hyperplastic lesions regressed following removal of the carcinogenic stimulus, but later lesions appeared to be irreversible. These animal systems appear useful in providing opportunities for investigations relevant to human bladder cancer.

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  PubMed