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- BookMario D. Cordero, Benoit Viollet, editors.Contents:
Part I: AMPK in health
Structure and Regulation of AMPK
AMPK Regulation of Carbohydrate Metabolism
AMPK Regulation of Lipid Metabolism
AMPK Regulation of Protein Metabolism
AMPK Regulation of cell growth, apoptosis, autophagy and bioenergetics
AMPK Regulation of immunology
AMPK and Stem Cells
Part II: AMPK in the diseases
AMPK in metabolic diseases
AMPK in neurodegenerative diseases
AMPK in cardiovascular diseases
AMPK in cancer
AMPK in aging
AMPK in musculoskeletal diseases and pain
AMPK in pathogens
Part III: Pharmacology of AMPK
Metformin, new drugs and AMPK
Small molecules and AMPK
Nutraceutical compounds and AMPK
Part IV: Methods of study in AMPK
Animal models
In vitro study methods.Digital Access Springer 2016 - ArticleCooke ED, Dawson MH, Ibbotson RM, Bowcock SA, Ainsworth ME, Pilcher MF.J Bone Joint Surg Am. 1977 Jun;59(4):496-500.In a double-blind, randomized trial of orally administered hydroxychloroquine sulphate in the prevention of venous thromboembolism after elective surgery on the hip, the drug or a placebo was given to fifty consecutive patients. Therapy was commenced on the day before the operation and continued for fourteen days. The diagnosis of deep venous thrombosis was made by daily thermographic scanning of the legs and confirmed by phlebography. The diagnosis of pulmonary embolism was made by perfusion lung scanning. No significant difference in the incidence of thromboembolism was found between treated and control groups. The results provide evidence that substances which reduce the incidence of thromboembolism in general surgery may not be effective in operations on the hip.