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  • Book
    Risto J. Rintala, Mikko Pakarinen, Tomas Wester, editors.
    Summary: This book provides readers with a succinct but comprehensive overview of current concepts relating to intestinal failure, including its treatment, with a particular focus on recent advancements. The opening chapters address basic aspects of intestinal failure, including etiology, clinical pathophysiology, physiology of intestinal adaptation, and intestinal microbiota. The complications of intestinal failure, such as bacterial overgrowth and intestinal failure-associated liver disease, are then discussed. A series of chapters specifically address important strategies in the nutritional, pharmacological, and surgical treatment of intestinal failure as well as the concept of intestinal rehabilitation. Finally, two significant emerging developments are considered: regenerative medicine and distraction enterogenesis. The authors are internationally recognized experts from Europe and North America who are ideally placed to describe current knowledge and progress in the field.

    Contents:
    Intestinal failure in children
    Short Bowel Syndrome-Intestinal Adaptation
    Bacterial Overgrowth and Intestinal Microbiome
    Intestinal failure-associated liver disease
    Recent Advances in Nutritional Care of Patients with Intestinal Failure
    Pharmacological improvement of bowel function and adaptation
    Modern Intestinal rehabilitation and outcomes
    Serial transverse enteroplasty
    Longitudinal intestinal lengthening
    Controlled tissue expansion
    Pediatric small bowel transplantation
    an update
    Intestinal Regeneration
    distraction enterogenesis.
    Digital Access Springer 2016
  • Article
    Littman A, Welch R, Fruin RC, Aronson AR.
    Gastroenterology. 1977 Jul;73(1):6-10.
    Relief of duodenal ulcer pain by aluminum hydroxide gel (AG) was compared with that obtained by a dummy gel (DG) in randomized trials. In 44 individual pain episodes, complete relief was obtained by 15-ml doses of AG in 79% and by DG in 45% (P less than 0.05). In 48 identical blind trials replicated at another hospital the difference was not significant. The gels were also tested against ulcer pain induced by intragastric acid instillation (Palmer test) in 35 patients; pain was relieved by AG in 63% and by DG in 62%. Presumed effectiveness in terminating ulcer episodes was studied in 65 patients admitted for pain; 37 received milk and cream hourly and 28 did not. All were treated with 15 ml of AG or DG during waking hours. Median time for complete disappearance of spontaneous pain was 3 days for AG and 7 days for DG, the same in both groups. In all patients the acid instillation test was repeated every few days. For the milk and cream group it became negative after 4 days with AG and after 6 days with DG. In 18 patients with gastric ulcer treated for 4 weeks AG led to greater reductions in size than did DG. A number of these trials indicate AG to be more effective than DG, but sampling and other methodological problems limit the certainty of any conclusions.
    Digital Access Access Options