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  • Book
    edited by Yehuda Shoenfeld, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, ... Show More Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, and Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel, Nancy Agmon-Levin, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel, Noel R. Rose, Department of Pathology, Department of Molecular Microbiology and Immunology, the Center for Autoimmune Disease Research, the Johns Hopkins Schools of Medicine and Public Health, Baltimore, Maryland, USA.
    Digital Access ClinicalKey 2015
  • Article
    Mroczek WJ, Moir D, Davidov ME, Finnerty FA.
    Am J Cardiol. 1977 May 26;39(6):808-12.
    The effects of various levels of sodium intake and loop diuretic (furosemide) administration upon arterial pressure and renal function were studied in 11 patients with impaired renal function and essential hypertension. The patients were hospitalized in a metabolic ward and continued taking their usual antihypertensive medications. After a stabilization period, all patients followed the following regiments for 5 to 7 days: period I, 20 mEq sodium diet without diuretic administration; period II, 80 mEq sodium diet and furosemide, 80 mg daily; and period III, 200 mEq sodium diet and furosemide, 240 mg daily. Supine diastolic pressure was lower (P is less than 0.05) during period II than during period I and both supine and standing systolic and diastolic pressures were significantly lower in period III than in period I (P is less than 0.01). No significant differences in the renal clearance of inulin were noted between any of the study periods. In patients with essential hypertension and impaired renal function, consumption of a moderate or liberal sodium diet combined with administration of a loop diuretic agent (furosemide) appears to result in better control of arterial pressure without significant changes in renal function than does strict sodium restriction without diuretic administration.
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