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  • Book
    Thomas J. Inzana, editor.
    Contents:
    Taxonomy of Histophilus somni
    Histophilosis as a Natural Disease
    Histophilus somni Genomics and Genetics
    Interactions on Histophilus somni with Host Cells
    Histophilus somni Surface Proteins
    Host Immune Response to Histophilus somni
    The Many Facets of Lipooligosaccharide as a Virulence Factor of Histophilus somni
    Exopolysaccharide Production and Biofilm Formation by Histophilus somni.
    Digital Access Springer 2016
    Access via Current topics in microbiology and immunology ; 2016; 396
    Location
    Version
    Call Number
    Items
    Current topics in microbiology and immunology ; 2016; 396
    2016
  • Article
    Henry SA, Atkinson KD, Kolat AI, Culbertson MR.
    J Bacteriol. 1977 Apr;130(1):472-84.
    Upon starvation for inositol, a phospholipid precursor, an inositol-requiring mutant of Saccharomyces cerevisiae has been shown to die if all other conditions are growth supporting. The growth and metabolism of inositol-starved cells has been investigated in order to determine the physiological state leading to "inositolless death". The synthesis of the major inositol-containing phospholipid ceases within 30 min after the removal of inositol from the growth medium. The cells, however, continue in an apparently normal fashion for one generation (2 h under the growth conditions used in this study). The cessation of cell division is not preceded or accompanied by any detectable change in the rate of macromolecular synthesis. When cell division ceases, the cells remain constant in volume, whereas macromolecular synthesis continues at first at an unchanged rate and eventually at a decreasing rate. Macromolecular synthesis terminates after about 4 h of inositol starvation, at approximately the time when the cells begin to die. Cell death is also accompanied by a decline in cellular potassium and adenosine triphosphate levels. The cells can be protected from inositolless death by several treatments that block cellular metabolism. It is concluded that inositol starvation results in a imbalance between the expansion of cell volume and the accumulation of cytoplasmic constituents. This imbalance is very likely the cause of inositolless death.
    Digital Access Access Options