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- BookPhilippe Courtet, editor.Summary: In this book international experts address a range of key current issues relating to suicide. The opening chapters discuss nosology, definitions, clinical determinants, and conceptual models of the suicide process and consider the evidence regarding potential biomarkers of suicide risk based on neuroscientific research. Adopting a neo-Durkheimian perspective, the role of various social factors in the genesis of suicidal behavior is then explored in depth. Practical user-friendly tools that facilitate risk assessment by clinicians are provided, and detailed consideration is given to efficient and innovative strategies for the prevention of suicide and the treatment of suicidal behavior, such as psychotherapy, psychopharmacological approaches, and effective organization of care, including surveillance and the use of online tools. The final part of the book focuses on the need for and development of a personalized approach within the field of suicide prevention. Understanding Suicide will be of interest to psychiatrists, psychologists, mental health professionals, general practitioners, researchers in suicidology, and students.
Contents:
Part I: Diagnostic & Clinical issues : DSM5
Nomenclature & definitions
Scales : Use of C-SSRS
Dimensions related to suicidal behaviour
Temperament in suicidal behaviour
Suicidal addiction
Part II: Models of suicidal process: Interpersonal theory
Suicidal crisis
Neurodevelopmental model
Part III: Biomarkers of suicide: Prospective studies
Genetics
Epigenetics
Social neurocognitions
Social & psychological
Biochemical markers
Translational models
Part IV: Neo-Durkheimian view: From society to groups at risk: Economic crisis
Psychiatric disorders: practical assessment
May a law change society: a Japanese model
Is it possible to survive in jail
Is the risk rising in children?
Is racism a killer?
Should we talk about religion?
Part V: Treatments of suicidal behaviour: Surveillance is a powerful tool to prevent suicidal acts
Preventing suicidality through online tools
What's wrong with antidepressants?
Lithium : the key anti-suicide agent
Antipsychotics
Anticonvulsants
Psychotherapy
Part VI: A need for Personalized Suicidology: Childhood maltreatment
Early detection in families
Should we consider the gender?
Is Pharmacoepidemiology really useful?
Pharmacogenetics
Endophenotypes based prevention. - ArticleBratlid D.Acta Pathol Microbiol Scand C. 1977 Feb;85(1):17-20.A new procedure for spectrophotometric determination of bacteriolytic activity in biological fluids is described. The method uses Micrococcus lysodeikticus cells as substrate. By inactivation of the sample through pre-incubation in ice-water, a large number of samples can be prepared and analysed simultaneously. The necessity of performing the whole analysis in the photometer for one sample at the time is thus eliminated. By measuring the increase in transmission at 570 nm after incubation of the samples at 37 degrees C a relatively long reaction time and wide concentration range is obtained. This makes the results quite precise and reproducible. The method has been used to determine the bacteriolytic activity in serum of healthy adults. Men have significantly higher levels than women.