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  Sickle Cell Anemia-- from Basic Science to Clinical Practice

  Fernando Ferreira Costa, Nicola Conran, editors.

  Summary: Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease's pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.

  Digital Access Springer 2016
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• Article

  O nekotorykh osobennostiakh formirovaniia épidemicheskogo protsessa pri dizenterii v trekh nebol'shikh gorodakh [Formation of the dysentery epidemic process in three small towns].

  Aleksandrovskaia IM, Solodovnikov IuP.

  Zh Mikrobiol Epidemiol Immunobiol. 1977(1):122-7.

  Data are presented concerning the epidemiological analysis of Sonnei dysentery outbreaks in three towns connected by common nutrition and water supply. The epidemic processes in these populated localites were strongly interrelated. Possibilities of the effect of the water factor on the extent of Sonnei dysentery incidence were studied as well. The results of studies led to the conclusion on the presence of numerous action forms of the water factor which should be taken into consideration in carrying out prophylactic and antiepidemic measures in Sonnei dysentery.

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