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  • Book
    Ajay K Khanna, Satyendra K Tiwary, editors.
    Summary: This book focuses on the clinical evaluation and management of ulcers of the lower limbs. There are numerous causes for ulceration in the lower limbs and each variety requires careful clinical evaluation and management approach. In 29 chapters, written by highly experienced surgeons, the book covers prevalence, types, healing mechanisms, clinical evaluation and microbiology of the ulcers, followed by detailed review of each ulcer variety. Chapters on pyoderma gangrenosum, diabetic foot, grafts and flaps, amputation, pain control strategy and documentation of these cases provide a complete coverage from management stand-point. The book is essential reading not only for general surgeons and vascular surgeons, but also has relevance for orthopedic surgeons, podiatrists, dermatologists and oncologists who manage such cases. Also serves as reference guide for post-graduate examination.

    Contents:
    Prevalence
    Impact of Ulceration
    Types of Ulcer
    Healing of Ulcer
    Clinical anatomy of Lower Extremity
    Approach to a case of Ulcer of Lower extremity
    Investigations for ulcer of Lower Extremity
    Microbiology of Ulcer
    Venous Ulcer
    Arterial ulcer
    Neuropathic Ulcer
    Infective Ulcer
    Diabetic Foot
    Lymphatic Ulcer
    Necrotising Fasciitis
    Pressure Ulcers
    Squamous Cell carcinoma
    Melanoma
    Basal Cell Carcinoma
    Sarcomas of Extremities presenting as ulceration
    Self Inflicted Ulceration
    Pyoderma Gangrenosum
    Vasculitis and Ulceration
    Unusual causes of lower extremity ulceration
    Grafts and Flaps for wound coverage
    Amputation
    Pain Control
    Documentation.
    Digital Access Springer 2016
  • Article
    Jensen P, Winger L, Rasmussen H, Nowell P.
    Biochim Biophys Acta. 1977 Feb 28;496(2):374-83.
    The mitogenic action of the divalent ionophore A23187 was confirmed and shown to be very sensitive to changes in extracellular calcium ion concentration. At optimal calcium and ionophore concentrations, an increase in [3H]-thymidine incorporation was seen that was similar to that seen after phytohemagglutinin addition. A calcium-dependent stimulation of alpha-aminoisobutyric acid transport was also seen after A23187 addition. Studies with three inhibitors demonstrate a similarity between proliferation induced by phytohemagglutinin and by A23187. Isoproterenol (10(-4) M) and ouabain (10(-7) M) blocked the effects of phytohemagglutinin and A23187. A drug, D-600 that has been shown to block calcium channels in cardiac muscle, inhibited proliferation induced by either phytohemagglutinin or A23187. This concentration of D600 had no effect on either phytohemagglutinin- or A23187-induced 45Ca2+ uptake. Furthermore, the (+) and (-) isomers separated from racemic D600, which have been shown to block sodium and calcium channels respectively in smooth muscle, had equal potency in blocking lymphocyte proliferation.
    Digital Access Access Options