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  • Book
    Rudolph M. Navari, editor.
    Contents:
    1. Introduction
    2. The physiology and pharmacology of nausea and vomiting induced by anticancer chemotherapy in humans
    3. First-generation 5-HT3 receptor antagonists
    4. Palonosetron
    5. The role of neurokinin-1 receptor antagonists in CINV
    6. Olanzapine for the prevention of chemotherapy-induced nausea and vomiting
    7. Gabapentin for the prevention of CINV
    8. Prevention of CINV in patients receiving high-dose multiple-day chemotherapy
    9. Clinical management of CINV
    10. Treatment of chemotherapy-induced nausea
    11. Conclusions
    12. Future directions.
    Digital Access Springer 2016
  • Article
    Lee N, Cheng E, Inouye M.
    Biochim Biophys Acta. 1977 Mar 17;465(3):650-6.
    The infrared spectrum of a structural lipoprotein from the Escherichia coli outer membrane indicated the lipoprotein had an alpha-helical conformation but no sign for the existence of beta-structures. From circular dichroism spectra of the lipoprotein, the alpha-helical content of the protein was found to be as high as 88% in 0.01-0.03% sodium dodecyl sulfate in the presence of 10(-5) M Mg2+ at pH 7.1 and 23 degrees C. When sodium dodecyl sulfate concentration increased higher than 0.1%, the alpha-helical content of the lipoprotein decreased to about 57%. Divalent cations, such as Mg2+ and Mn2+, were found to increase the helical content of the lipoprotein. The high alpha-helical content of the lipoprotein was observed in a wide range of temperatures (23 to 55 degrees C). The significance of the high alpha-helical content of the lipoprotein is discussed in light of the three-dimensional molecular models of the lipoprotein proposed previously.
    Digital Access Access Options