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  • Book
    Morris F. Collen, Marion J. Ball, editors.
    Summary: This is a meticulously detailed chronological record of significant events in the history of medical informatics and their impact on direct patient care and clinical research, offering a representative sampling of published contributions to the field. The History of Medical Informatics in the United States has been restructured within this new edition, reflecting the transformation medical informatics has undergone in the years since 1990. The systems that were once exclusively institutionally driven - hospital, multihospital, and outpatient information systems - are today joined by systems that are driven by clinical subspecialties, nursing, pathology, clinical laboratory, pharmacy, imaging, and more. At the core is the person - not the clinician, not the institution - whose health all these systems are designed to serve. A group of world-renowned authors have joined forces with Dr Marion Ball to bring Dr Collen's incredible work to press. These recognized leaders in medical informatics, many of whom are recipients of the Morris F. Collen Award in Medical Informatics and were friends of or mentored by Dr Collen, carefully reviewed, editing and updating his draft chapters. This has resulted in the most thorough history of the subject imaginable, and also provides readers with a roadmap for the subject well into later in the century.
    Digital Access Springer 2015
  • Article
    Eskay RL, Mical RS, Porter JC.
    Endocrinology. 1977 Feb;100(2):263-70.
    The concentration of luteinizing hormone releasing hormone (LHRH) in hypophysial portal plasma was determined in pentobarbital anesthetized,intact and castrated rats of both sexes, including proestrous rats following electrochemical stimulation of the medial preoptic area (MPOA). Mean LHRH levels in portal plasma obtained between 1400--1700 h from estrous and diestrous rats and from rats ovariectomized for 8 weeks were similar and ranged from 50--55 pg/ml, but the LHRH levels in proestrous rats were less than 12 pg/ml. In addition, hypophysial portal plasma collected during 1100 to 1400 h from animals orchidectomized for 8 weeks and from intact male rats contained mean LHRH concentrations that ranged from 50--65 pg/ml and 30--35 pg/ml, respectively. Electrochemical stimulation of the MPOA in the female rat on the afternoon of proestrus resulted in a marked increase in the concentration of LHRH in portal plasma. LHRH levels in portal plasma during the 0 to 30, 30 to 60, 60 to 90, 90 to 120, and 120 to 150-min periods after electrochemical stimulation of the MPOA were 105 +/- 24.2, 61 +/- 10.8, 51 +/- 8.2, 36 +/- 5.3, and 32 +/- 4.1 pg/ml, respectively. LHRH levels in portal plasma from the unstimulated rats were not detectable (less than 12 pg/ml) in most of the animals. In another group of proestrous rats, the effect of rabbit anti-LHRH serum or normal rabbit serum (NRS) on the release of LH after electrochemical stimulation of MPOA was examined. Pretreatment of proestrous rats with anti-LHRH serum blocked the release of LH due to MPOA stimulation, whereas pretreatment with NRS did not inhibit LH release. On the basis of these findings, it is concluded that electro-chemical stimulation of the MPOA in proestrous rats increases LHRH levels in portal blood and that the enhanced secretion of LHRH stimulates the release of LH from the pituitary gland.
    Digital Access Access Options