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• Book

  Transcriptomics and gene regulation

  Jiaqian Wu, Editor ; Honor editor, Dong Kim.

  Contents:
  The Analyses of Global Gene Expression and Transcription Factor Regulation
  Global Approaches to Alternative Splicing and its Regulation
  Recent Advances and Open Questions
  Long Non-coding RNAs: Critical Regulators for Cell Lineage Commitment in the Central Nervous System
  Gene expression models of signaling pathways
  From Gene Expression to Disease Phenotypes: Network-Based Approaches to Study Complex Human Diseases
  Introduction to Isoform Sequencing using Pacific Biosciences Technology (Iso-Seq)
  Systematic and Integrative Analysis of Gene Expression to Identify Feature Genes Underlying Human Diseases.

  Digital Access Springer 2016
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• Article

  Synthesis of guanosine 5'-diphosphate, 3'-diphosphate in spot mutants of Escherichia coli.

  de Boer HA, Weyer WJ, de Boer JG, van der Heide S, Gruber M.

  Biochim Biophys Acta. 1977 Jan 20;474(2):165-72.

  The synthesis of ppGpp in spoT- mutants of Escherichia coli has been invesitgated. In these mutants the first-order rate constant for ppGpp breakdown is low, and pppGpp is barely detectable. It is shown that the rate of pppGpp, and hence ppGpp, synthesis is strongly reduced compared with that observed in spot+ strains. The low rate of magic spot synthesis satisfactorily explains the low levels of pppGpp in spoT- mutants. The pentaphosphate very probably is the precursor of ppGpp as it is in wild-type, i.e. spoT+, strains.

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  PubMed