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  • Book
    Peter Igaz, editor.
    Summary: MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.

    Contents:
    Part I: General features and technical issues related to circulating microRNA
    1. Introduction to microRNAs: biogenesis, action, relevance of tissue microRNAs in disease pathogenesis, diagnosis and therapy. The concept of circulating microRNAs
    2. Extracellular microRNAs in membrane vesicles and non-vesicular carriers
    3. Technical aspects related to the analysis of circulating microRNAs
    Part II: Diagnostic relevance of circulating microRNAs
    4. Circulating blood-borne microRNAs as biomarkers in solid tumors
    5. Circulating microRNA as biomarkers in hematological malignancies
    6 Circulating microRNAs as biomarkers in cardiovascular diseases
    7 Circulating microRNAs in neurodegenerative diseases
    8 Circulating extracellular microRNA in systemic autoimmunity
    9. Circulating microRNAs in inflammatory bowel diseases
    10. Circulating microRNAs in diabetes progression: discovery, validation and research translation
    11. Diagnostic relevance of microRNAs in other body fluids including urine, feces and saliva
    Part III: Potential biological relevance of circulating microRNA
    12 Circulating microRNAs as hormones
    intercellular and inter-organ conveyors of epigenetic information?
    13. Are circulating microRNAs involved in tumor surveillance?
    14.-Hypothetic interindividual and interspecies relevance of microRNAs released in body fluids.
    Digital Access Springer 2015
  • Book
    Helena Curtis.
    Print c1983
  • Article
    Lister J.
    Br J Anaesth. 1977 Jan;49(1):43-50.
    Paediatric surgery is a young specialty whose rapid growth in the United Kingdom has largely been as a result of the development of neonatal surgery in the past 20 years. A decreasing birth rate, and pre-natal diagnosis of some major congenital anormalies with the possibility of termination of pregnancy, are likely to prevent further increases to neonatal surgical units. Expansion of case material is likely to come from earlier attacks on congenital heart disease, and improvement in results is more likely to come from improved respiratory management than from the development of new surgical techniques.
    Digital Access Access Options