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- BookLuiz E. Bertassoni, Paulo G. Coelho, editors.Summary: This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist. Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters. While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes. We envision that this book will represent a valuable reference source for university and college faculties, post-doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues.
Contents:
3D printing and biofabrication for load bearing tissue engineering
Microfabrication of Cell-Laden Hydrogels for Engineering Mineralized and Load Bearing Tissues
Electrospinning of bioinspired polymer scaffolds
Bone tissue engineering challenges in oral & maxillofacial surgery
Engineering Pre-vascularized Scaffolds for Bone Regeneration
Morphogenic Peptides in Regeneration of Load Bearing Tissues
Osseointegration of Plateau Root Form Implants: Unique Healing Pathway leading to Haversian-Like Long-Term Morphology
Dentin matrix proteins in bone tissue engineering
Multiphasic, Multistructured and Hierarchical Strategies for Cartilage Regeneration
Anterior Cruciate Ligament: Structure, Injuries and Regenerative Treatments
Hard-soft tissue interface engineering
Cementum and periodontal ligament regeneration
Amelogenin in enamel tissue engineering
Whole tooth regeneration as a future dental treatment.Access via Advances in experimental medicine and biology ; 2015; 881LocationVersionCall NumberItems - ArticleSchwartz JT, Graham DY.Ann Surg. 1977 Jan;185(1):64-6.Toothpicks have been used since antiquity as instruments for mouth cleansing and as eating utensils. Toothpick injury to the gastrointestinal tract is often suspected only at the time of operation because patients rarely relate a history of swallowing toothpicks and most toothpicks are not radiopaque. The spectrum of toothpick injury to the gastrointestinal tract is illustrated by 5 patients who developed toothpick perforation of the gastrointestinal tract. Two patients died as a result of complications of toothpick injury, one of these presenting with recurrent gram negative sepsis with multiple organisms due to a duodenal-inferior vena caval toothpick fistula. In two instances the toothpicks were removed at operation and one that was penetrating the duodenum was removed with a fiberoptic duodenoscope.