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• Book

  Gene delivery and therapy for neurological disorders

  edited by Xuenong Bo, Joost Verhaagen.

  Contents:
  Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System
  Lentiviral Vectors for Gene Delivery to the Nervous System
  Gene Therapy for Parkinson's Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF)
  Gene Delivery and Gene Therapy for Alzheimer's Disease
  Gene Therapy for Huntington's Disease
  Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury
  Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors
  Targeted Gene Therapy for Ischemic Stroke
  Adeno-Associated Viral Gene Therapy for Retinal Disorders
  Gene Therapy for Epilepsies
  AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement
  Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice
  Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain?
  Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models

  Digital Access Springer 2015
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• Article

  Thyroglobulin biosynthesis in a larval (ammocoete) and adult freshwater lamprey (Lampetra planeri Bl.).

  Monaco F, Andreoli M, La Posta A, Roche J.

  Comp Biochem Physiol B. 1978;60(1):87-91.

  1. The biosynthesis of 18-19S thyroglobulin has been studied in a larval and adult freshwater lamprey (Lampetra planeri Bl.). 2. In vivo and in vitro experiments have been performed by injecting into the coelomic cavity or by incubating branchial region labeled constituents of Tg of higher vertebrates (125I, [3H]leucine and various [3H]carbohydrates). 3. Larvae (ammocoetes) and adults incorporate all labels into thyroglobulin (18-19S Tg), containing a small proportion of labeled T3 and T4, as identified by paper chromatography, and very minute amounts of stable iodine. 4. In adults, the biosynthesis of 18-19S Tg proceeds much more rapidly and the labels are incorporated in higher percentage than in larvae. 5. The demonstration of the biosynthesis of the specific thyroid protein, 18-19S Tg, in larvae indicates that the biochemical mechanism of hormonogenesis is present in larval endostyle before the morphological differentiation of thyroid cells and follicles occurring during metamorphosis. 6. Some 18-19S Tg is apparently stored in the endostyle.

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