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  • Book
    edited by Manfred Ogris, David Oupicky.
    Contents:
    Toxicological aspects for nanomaterial in humans
    Lactate dehydrogenase assay for assessment of polycation cytotoxicity
    Combined fluorimetric caspase 3/7 assay and bradford protein determination for assessment of polycation-mediated cytotoxicity
    Anti-PEG igm production via a PEGylated nano-carrier system for nucleic acid delivery
    Near-infrared optical imaging of nucleic acid nanocarriers in vivo
    Lipids for nucleic acid delivery: Synthesis and particle formation
    Histidine-rich cationic amphipathic peptides for plasmid DNA and siRNA delivery
    Synthesis of polyethylenimine-based nanocarriers for systemic tumor targeting of nucleic acids
    Synthesis of bioreducible polycations with controlled topologies
    Lyophilization of synthetic gene carriers
    Surface- and hydrogel-mediated delivery of nucleic acid nanoparticles
    Layer-by-layer assembled gold nanoparticles for the delivery of nucleic acids
    In situ AFM analysis investigating disassembly of DNA nanoparticles and nano-films
    Enhancing nucleic acid delivery with ultrasound and microbubbles
    Magnetic and acoustically active microbubbles loaded with nucleic acids for gene delivery
    Synthesis of lipidic magnetic nanoparticles for nucleic acid delivery
    Lipopeptide delivery of siRNA to the central nervous system
    Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery
    Liver-targeted gene delivery through retrograde intrabiliary infusion.
    Digital Access Springer 2013
  • Article
    Massip P, Kitzis MD, Tran VT, Armengaud MJ, Armengaud M.
    Rev Infect Dis. 1979 Jan-Feb;1(1):132-3.
    The penetration of cefoxitin into the cerebrospinal fluid (CSF) after slow intravenous infusion of 50-100 mg/kg over 1 hr was studied in normal dogs and in dogs with meningitis experimentally induced by intrathecal injection of 10(9) Staphylococcus aureus. With healthy dogs the peak CSF concentration of 1 microgram of cefoxitin/ml was found to correspond with a serum level of 120 micrograms/ml. With administration of probenecid the CSF level was 1.5 micrograms of cefoxitin/ml. Doubling the dose from 50 to 100 mg/kg resulted in a CSF concentration of 2 micrograms of cefoxitin/ml. In the CSF of animals with meningitis, a peak concentration of 10 micrograms of cefoxitin/ml was obtained 90 min after the start of the infusion, and 5 micrograms/ml was still present at 240 min. The peak level in CSF of animals with meningitis was about 10% of the simultaneous level in serum.
    Digital Access Access Options