ArticleRomani L, Bianchi R, Nardelli B, Circolo A, Andrielli M.
Boll Soc Ital Biol Sper. 1979 Oct 15;55(19):1981-7.
Specific cytotoxic T cells were obtained by coculturing "in vitro" normal spleen cells with inactivated histocompatible DTIC-altered lymphoma cells. The "in vivo" antitumor activity of such sensitized lymphocytes was evaluated by injecting a mixture of lymphocytes + tumor into the brains of lethally irradiated syngenic mice. The results indicated that such lymphocytes demonstrate antitumor activity against the same tumor but not against unrelated tumors.