1. Introduction -- 2. Discovery and validation of biomarkers based on computational models of normal and pathological hippocampal rhythms -- 3. DCM conductance based models and clinical applications -- 4. Computational models of closed-loop deep brain stimulation -- 5. A multiscale "working brain" model -- 6. How to render neural fields more realistic -- 7. Multilevel computational modelling in epilepsy: classical studies and recent advances -- 8. Computational modeling of neuronal dysfunction at molecular level validates the role of single neurons in circuit functions in cerebellum granular layer -- 9. Modelling cortical and thalamocortical synaptic loss and compensation mechanism in Alzheimer's disease -- 10. Toward networks from spikes -- 11. Epileptogenic networks: applying network analysis techniques to human seizure activity -- Index.