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  • Book
    Bruce E. Torbett, David S. Goodsell, Douglas D. Richman, editors.
    Summary: This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle.

    Contents:
    HIV Therapy: Looking Towards the Future
    Computational challenges of structure-based approaches applied to HIV
    Nucleocapsid Protein: A Desirable Target For Future Therapies Against HIV-1
    HIV-1 integrase multimerization as a therapeutic target
    Targeting HIV transcription: The quest for a functional cure
    Targeting the HIV RNA Genome: High-Hanging Fruit Only Needs a Longer Ladder
    HIV-1 Gag: An Emerging Target for Antiretroviral Therapy
    The Triple Threat of HIV-1 Protease Inhibitors
    Illustrations of the HIV Life Cycle.
    Digital Access Springer 2015
    Access via Current topics in microbiology and immunology ; 2015; 389
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    Current topics in microbiology and immunology ; 2015; 389
    2015
  • Article
    Cancro MP, Wylie DE, Gerhard W, Klinman NR.
    Proc Natl Acad Sci U S A. 1979 Dec;76(12):6577-81.
    The B-cell response of 12- to 14-day old BALB/c mice to the hemagglutinin molecule of influenzae virus A/PR/8/34(H0N1) has been examined with monoclonal antibodies obtained by the splenic focus technique. An analysis of the specificity of these antibodies with a panel of heterologous viruses indicates that the antibody repertoire is highly restricted at an intermediate stage in postnatal development of the immune system. In toto, only 10 distinct reactivity patterns have been observed in an analysis of 72 antibodies derived from 28 donors. This contrasts with a substantially more diverse repertoire present in nonimmune and immune adult populations. The neonatal antibody specificities do not appear to be a random sampling of adult specificities, because several clonotypes (as defined by reactivity pattern) frequently found in neonates are rare or absent in adults. Most importantly, the vast majority of adult clonotypes are absent from the neonatal repertoire. These findings indicate that, at a developmental stage when the B-cell repertoire contains at least 10(6) clonotypes, the repertoire of genetically identical individuals is shared. This is consistent with a diversification process that is highly patterned and genetically determined. Furthermore, because 12- to 14-day-old neonates exhibit a diversified but definable hemagglutinin-specific B-cell repertoire, this experimental system should enable precise analyses of genetic and environmental influences on repertoire expression.
    Digital Access Access Options