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  • Book
    Mohsen El Kossi, Arif Khwaja, Meguid El Nahas, editors.
    Contents:
    Management of ADPKD
    Secondary Glomerular Disease Lupus Nephritis
    ANCA-Associated Vasculitis
    Acute Kidney Injury
    Chronic Kidney Disease
    Anaemia in Chronic Kidney Disease (CKD)
    Lipids and Chronic Kidney Disease
    Chronic Kidney Disease with Mineral and Bone Disorder (CKD-MBD)
    Diabetic Nephropathy
    Primary Glomerular Disease
    Hemodialysis
    Peritoneal Dialysis
    Transplantation.
    Digital Access Springer 2015
  • Article
    Roberts D, Kidd W, Pratt CB, Peck C, Grinnel J.
    Cancer. 1979 Sep;44(3):881-90.
    The method of Arons et al. (Cancer Res. 35:2033-2038, 1975) for assaying methotrexate (MTX) was used to monitor serum levels of the drug attained in 18 patients with osteosarcomas. The patients received either 100 mg or 200 mg of MTX/kg via a 6-hour infusion. With one fatal exception, unacceptable toxicity to MTX was prevented by leucovorin. Serum levels of the drug were assayed routinely at 6, 12, and 18 hours after termination of the infusion. Although significantly higher serum levels of MTX were observed at 6 hours after the infusion of 200 mg MTX/kg than after 100 mg/kg, the variation in rate of clearance of individual patients masked any subsequent dosage-related differences. The mean half-time for clearance of MTX was similar irrespective of the dosage of MTX and was 2.91 +/- 1.51 hr for 53 treatments. The single incidence of toxicity, requiring hospitalization, was accompanied with markedly higher serum levels of MTX at 18 hours, but not at either 6 or 12 hours after termination of the drug infusion, and by a slightly slower rate of clearance, 6.2 hours. Certain minor adaptations were incorporated in the original assay to simplify the analysis of data.
    Digital Access Access Options