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  • Book
    Lisa A. Newman, Jessica M. Bensenhaver, editors.
    Summary: This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing "true" DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer. Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer.

    Contents:
    Epidemiology of Ductal Carcinoma In Situ
    Role of Screening Mammography in Early Detection/Outcome from Breast Cancer
    Imaging DCIS: Digital/Film Screening Mammography, Tomosynthesis, MRI, Ultrasonography
    Pathology of Ductal Carcinoma In Situ: Features and Diagnostic Challenges
    Molecular Markers in DCIS
    History of Ductal Carcinoma In Situ Management Based Upon Data from Prospective, Randomized Clinical Trials
    Extent and Role of Margin Control for DCIS Managed by Breast-Conserving Surgery
    Ductal Carcinoma In Situ Treated With Breast Conserving Surgery Alone
    DCIS Managed with BCS: Whole-Breast XRT vs. Partial Breast XRT
    Anti-HER2/neu Therapy in DCIS
    Role of Genetic Profiling and Recurrence Scores in Treatment Planning for DCIS
    DCIS and Sentinel Lymph Node Biopsy
    Role of Postmastectomy Radiation for DCIS
    Monitoring and Surveillance Following DCIS Treatment
    DCIS and Hereditary Susceptibility for Breast Cancer
    Introduction, Evolution and Application of the Van Nuys Prognostic Index in DCIS
    Disparities in DCIS Detection and Outcomes Related to Race/Ethnicity.
    Digital Access Springer 2015
  • Article
    Harm W.
    Mutat Res. 1979 Apr;60(2):121-33.
    Yeast photoreactivating enzyme (PRE), preilluminated with wavelengths ranging from the near-UV to the red spectral region, forms with 254 nm-irradiated transforming DNA of Haemophilus influenzae enzyme-substrate complexes that are more efficiently photorepaired than complexes formed from non-preilluminated PRE. The action spectrum for this "preillumination effect", previously shown to have a maximum in the near-UV region, has another maximum near 577 nm. In complexes formed from non-preilluminated PRE the repair probability per incident photon is only about 25% of that in complexes formed from preilluminated PRE, if low-intensity photoreactivating light is applied continuously or as a sequence of flashes. However, photoreactivating light in the form of a single, high-intensity flash of 1 msec duration raises the repair probability to greater than 50%. Two light flashes, discharged with a delay of slightly more than a millisecond, may already achieve less photorepair than the same energy given as a single flash. These results are explained by the assumption that the great majority of PRE molecules in a non-preilluminated preparation have reduced activity (of the order of 1/4 of maximal activity). These less reactive molecules form enzyme-substrate complexes ("non-activated complexes") in which the repair probability per incident photon is considerably increased if 2 or more photons are absorbed within a time period of the order of milliseconds. This phenomenon, tentatively termed "2-photon photolysis" does not occur in "activated complexes" (i.e. those formed form preilluminated enzyme). The data are compatible with suggestion that the first absorption leads to a metastable excited state of the complex, during which the repair probability is increased by absorption of another photon. The generally observed heterogeneity of the photolytic response of enzyme-substrate complexes can be partly explained by heterogeneity of PRE molecules regarding their activity. In particular, uncontrolled exposure of enzyme to almost any kind of room light before its experimental use can enhance the heterogeneity.
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