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- BookCatherine M. Greene, editor.Summary: The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohnℓ́ℓs disease, diabetes), and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those involved in drug development.
Contents:
The biology of microRNA
The biology of long non-coding RNA
microRNA regulation of neutrophil function
How non-coding RNAs contribute to macrophage polarization
Endogenous control of dendritic cell activation by miRNA
Noncoding RNA expression during viral infection: the long and the short of it
Wound inflammation: emerging role of miRNA
The importance of microRNAs in rheumatoid arthritis
MicroRNAs with impact on adipose tissue inflammation in obesity
The relationship between miR-29, NOD2 and Crohn's disease
The role of ncRNA in diabetes
ncRNA as diagnostics and prognostics for hepatocellular carcinoma. - ArticleErlichman C, Pringle JF, Quirt IC.Med Pediatr Oncol. 1979;6(2):115-9.The ectopic production of the beta-subunit of human chorionic gonadotropin (hCG) is described in a patient with an anaplastic carcinoma. After chemotherapy the marker decreased in a logarithmic fashion to undetectable levels but the neoplasm progressed and the patient died. The specificity of the beta-subunit of hCG is discussed. Discordance of the marker and clinical disease is pointed out, and several possible explanations are outlined. The lack of specificity of the beta-subunit of hCG and the discordance that it may exhibit means that its use in diagnosing and following disease progression may be limited.