Search
Filter Results
- Resource Type
- Article1
- Book1
- Book Digital1
- Article Type
- Case Reports1
- English Abstract1
- Result From
- Lane Catalog1
- PubMed1
-
Year
- Journal Title
- Dtsch Med Wochenschr1
Search Results
Sort by
- ArticleWilms K, Wiedmann KH, Castrillón-Oberndorfer WL.Dtsch Med Wochenschr. 1979 Jun 01;104(22):814-7.Mucosal ulceration and severe bone-marrow insufficiency with marked megaloblastic transformation occurred during treatment with triamterene in a patient with decompensated alcoholic liver cirrhosis and malnutrition. When the triamterene-containing preparation was stopped and folinic acid administered the haematological picture improved, but the patient died, with signs of hepatocellular insufficiency, of gastro-intestinal bleeding. The serum folic-acid level was markedly reduced due to the chronic malnutrition, while the vitamin B12 level was within normal limits. This observation indicates that when the pool of folic-acid coenzymes is reduced, triamterene can cause megaloblastic anaemia due to its folic-acid antagonism. Triamterene should, therefore, be given to patients with borderline folic-acid reservoirs, chronic alcoholism or during pregnancy, only under careful serial control of the blood picture.