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  • Book
    Jeremy Nuttall, editor.
    Summary: One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.

    Contents:
    Candidate Microbicides and Their Mechanisms of Action
    Microbicide Dosage Forms
    Preclinical Safety Evaluation
    Clinical Safety and Pharmacology Trial
    Microbicides for Prevention of HIV Infection: Clinical Efficacy Trials
    Rectal Microbicide Development
    Developing Regulatory Strategy for Microbicides
    Preparing for Microbicide Introduction, Rollout and Sustained Access.
    Digital Access Springer 2014
    Access via Current topics in microbiology and immunology ; 2014; 383
    Location
    Version
    Call Number
    Items
    Current topics in microbiology and immunology ; 2014; 383
    2014
  • Article
    Zapanta M, Aldo-Benson M, Biegel A, Madura J.
    Arthritis Rheum. 1979 Jul;22(7):711-7.
    Arthritis is a common complication of small bowel bypass, occurring in 5-20% of the postsurgical patients. Thirteen patients with arthritis related to jejunoileal bypass were studied. These patients had a symmetrical polyarthritis, and 8 also had extraarticular connective tissue disease manifestations. Immunologic evaluations were done on these patients and on a control group of 12 age- and sex-matched postintestinal bypass patients without arthritis. The incidence of positive ANA, rheumatoid factors, immune complexes, and antibodies to intestinal flora was the same in both groups. Patients in both groups showed similar changes in numbers of circulating T and B lymphocytes. More patients in the group with arthritis than in the control group had elevated IgA levels (38% versus 8%), but the difference was not significant (P less than 0.05). This study demonstrates that immunologic abnormalities occur after jejeunoileal bypass irrespective of the onset of arthritis or related symptoms. No specific immunologic abnormalities could be associated with the arthritis occurring after small bowel bypass.
    Digital Access Access Options