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- BookM. Gabriel Khan.Summary: This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explored, with answers given to the question: do beta blockers and diuretics really cause diabetes? Properties, dosage, side effects, potential salutary benefits, and drawbacks on virtually all commercially available cardiac drugs are examined. This revised edition is thoroughly updated and addresses the entire spectrum of heart disorders, such as hypertension, angina, myocardial infarction, heart failure, arrhythmias, cardiac arrest, and dyslipidemias. New chapters include endocrine heart diseases, management of cardiomyopathies, and newer agents. In addition, topics such as cardiac drugs in pregnancy and lactation and drug interactions are covered. Cardiac Drug Therapy, Eighth Edition, is an authoritative and clinically relevant resource for cardiologists, cardiology fellows, and internists.
Contents:
Beta-Blockers: The Cornerstone of Cardiac Drug Therapy
Beta-Blocker Controversies
Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers
ACE Inhibitor Controversies
Calcium Antagonists (Calcium Channel Blockers)
Calcium Antagonist Controversies
Diuretics
Hypertension
Hypertension Controversies
Angina
Acute Myocardial Infarction
Heart Failure
Heart Failure Controversies
Management of Cardiac Arrhythmias
Cardiac Arrest
Management of Infective Endocarditis
Dyslipidemias
Endocrine Heart Diseases
Antiplatelet Agents, Anticoagulants, Factor XA Inhibitors, Thrombin Inhibitors
Cardiac Drugs During Pregnancy and Lactation
Effects of Drug Interactions
Hallmark Clinical Trials
Management of Cardiomyopathies
Newer Agents. - ArticleRyan JL, Shinitzky M.Eur J Immunol. 1979 Feb;9(2):171-5.Preparations of gangliosides from bovine brain contain material which acts as a strong mitogen on murine spleen cells. This material is highly lipophilic and co-purifies with the ganglioside fraction. It contains saccharides of a similar composition to those found in monosialogangliosides, as well as a spinogsine base and an appreciable amount of peptide. The common brain gangliosides GM1, GD1a and GD1b, on the other hand, are not mitogenic and act as suppressors of the mitogenic activity of bacterial lipopolysaccharide on murine spleen cells. Both the mitogenically active and suppressive fractions of bovine brain glycosphingolipid were found to act exclusively on B lymphocytes. Since gangliosides and related compounds are components of plasma membranes and of amphipathic nature, they may passively migrate between the lymphocyte subpopulations and thus act as physiological modulators of immune responses.